DOI: http://dx.doi.org/10.18203/2349-3259.ijct20151237

Comparison of bone mineral density and serum minerals in pre and post-menopausal women

Sasmita Mishra, M. Manju, B. D. Toora, S. Mohan, B. P. Venkatesh

Abstract


Background: Osteoporosis is a disease that weakens bones, increasing the risk of sudden and unexpected fractures. Literally meaning “porous bone”, it results in an increased loss of bone mass and strength. The disease often progresses without any symptoms or pain. Though the exact cause is not known it can be prevented. After age 35, bone breakdown outpaces bone build-up, resulting in a gradual loss of bone mass. Once this loss of bone reaches a certain point, a person has osteoporosis. After menopause, bone resorption (breakdown) outpaces the building of new bone. Osteoporosis is a silent disease, reflected only in a low bone density, till a fracture occurs.One of the most rapidly emerging health problems in the postmenopausal women is osteoporosis. It is now realized that, osteoporotic fractures are a major cause of morbidity and mortality in India in the elderly women population. Aim:To study the correlation between serum minerals and Bone Mineral Density (BMD) in pre and postmenopausal women.

Methods: This study was designed to find out the serum mineral levels and its correlation with bone mineral density in pre and post-menopausal women. The present study was a cross-sectional study. 40 women from each group i.e. premenopausal and postmenopausal women were selected for the study with no medical, surgical or gynaecological abnormalities. The Bone Mineral Density (BMD) was measured by Bone Densitometer and classified as normal, osteopenia and osteoporosis according to T-score. Serum minerals were measured in autoanalyser. The data was analyzed using Microsoft excel 2007. For the comparison of values between the groups, students ‘t’ test was used, for the correlation, Pearson’s correlation coefficient was used.

Results: Around 80% of the post-menopausal women are osteoporotic. BMD scores were significantly low in postmenopausal women according to T-score along with significantly decreased Serum mineral levels when compared to premenopausal women. There was significant positive correlation between T-score and serum calcium and magnesium levels in postmenopausal women.

Conclusions: Our study suggests that peri and postmenopausal women should take magnesium rich foods also like whole grains, legumes, fruits and vegetables (especially dark-green, leafy vegetables) every day which will help to provide recommended intakes of magnesium and maintain normal storage levels of this mineral. If these foods are not available or serum levels are too low supplementation can be given in the form of tablets.


Keywords


Postmenopausal women, Osteoporosis, Serum calcium, Serum magnesium, Bone mineral density

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References


Bhattarai T, Bhattacharya K, Chaudhuri P, Sengupta P. Correlation of common biochemical markers for bone turnover, serum calcium, and alkaline phosphatase in post-menopausal women. Malays J Med Sci. 2014 Jan-Feb;21(1):58-61.

S. K. Deepthi, G. Amar Raghu Narayan, J. N. Naidu. Study of biochemical bone turnover markers in postmenopausal women leading to osteoporosis. Int J Appl Biol Pharmaceut Technol. 2012;3:301-5.

Prince RL, Devine A, Dick I, Criddle A, Kerr D, Kent N, et al. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Mineral Res. 1995;10(7):1068-75.

Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women - a randomized controlled trial. Am J Med. 1995;98:331-5.

McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium in modulating age-related increases in parathyroid function and bone resorption. Journal of Clinical Endocrinology Metabolisme 1996; 81: 1699.1996.

Fazlini MF, Suriah AR, Zaitun Y, Kandiah M, Chee WSS, Chan YM, et al. Calcium supplementation amongst postmenopausal women: effect on serum calcium, phosphorus and magnesium level. Int Food Res J. 2013;20(1):477-80.

Heaney RP, Marcus R, Feldman D, Kelsey J. Nutrition and risk of osteoporosis. In: Heaney RP, Marcus R, Feldman D, Kelsey J, eds. Osteoporosis. 4th ed. San Diego, California: Academy Press; 2001: 669-700.

Tabasum Parvez. Postmenopausal osteoporosis. JK Pract. 2004;11(4):281-3.

Maxwell H, Abernethy, Richard T. Flower. Micellar. Improvement of the Calmagite compleximetric measurement of magnesium in plasma. Clin Chem. 1982;28(3):520-2.

Seema Sharma, Sunila Khandelwal. Effective risk assessment tools for osteoporosis in the Indian menopausal female. J Midlife Health. 2010 Jul-Dec;1(2):79-85.

Nordin BEC. Calcium and osteoporosis. Nutrition. 1997;13:664-86.

Ho SC, Chen YM, Woo JL, Lam SS. High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study. J Clin Endocrinol Metab. 2004;89:2166-70.

Suzuki Y, Davison KS, Chilibeck PD. Total calcium intake is associated with cortical bone mineral density in a cohort of postmenopausal women not taking estrogen. J Nutr Health Aging. 2003;7:296-9.

McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrinol Metab. 1996;81:1699-703.

Nieves JW, Komar L, Cosman F, Lindsay R. Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis. Am J Clin Nutr. 1998;67:18-24.

Martini LA, Meyer J. Magnesium supplementation and bone turnover. Nutr Rev. 1999;57(7):227-9.

Sara Castiglioni, Alessandra Cazzaniga, Walter Albisetti, Jeanette A. M. Maier. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5:3022-33.

Allgrove J, Shaw NJ. Calcium and bone disorders in children and adolescents. In: Allgrove J, Shaw NJ, eds. Endocrine Development. 16th ed. Basel: Karger; 2009: 8-31.

Stendig-Lindberg G, Koeller W, Bauer A, Rob PM. Experimentally induced prolonged magnesium deficiency causes osteoporosis in the rat. Eur J Intern Med. 2004;15:97-107.

Tranquilli AL, Lucino E, Garzetti GG, Romanini C. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 1994;8:55-8.