Anti-ageing effects of CollabZen™ in healthy human volunteers: a randomized, double blind, placebo-controlled study


  • Mihir C. Gadani Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India
  • Sneha Badak Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India
  • Ratna Upadhyay Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India



CollabZenTM, Nutraceuticals, Skin ageing, Nutrition, Phytocompound


Background: There are several concerns related to combating signs of ageing. Considering the long-term safety concerns of cosmetic formulations, a safe and effective approach using nutritional supplements and naturals should be of great help. CollabZenTM is one such a blend of three plant materials known as Phyllanthus emblica, Camellia sinensis, and Coffea arabica, earlier tested for collagen building in human cells in-vitro. The current study aims to explore its potential as a nutraceutical product for skin ageing.

Methods: The study enrolled 64 volunteers both genders (mean age=45.75) with crow's feet wrinkles. One group (n=32) received a placebo capsule (Product A) and other group received CollabZenTM capsules (Product B). Dermatological parameters were assessed at 0th day, 4th and 8th week, and self-assessment questionnaires for efficacy and tolerance were collected on 4th and 8th week. The trial is registered at, CTRI/2022/10/046168.

Results: The results showed that product B (CollabZenTM) was significantly effective than the placebo in improving deep skin hydration on the face (p=0.009), increasing facial skin elasticity (p=0.001), and enhancing firmness (p=0.001) after 8 weeks. Participants in Group B reported higher levels of satisfaction regarding their perceived skin health compared to group A based on self-assessment at the 8th weeks (p<0.01). Moreover, only one volunteer in each group experienced mild intolerance at the end of 8th week, demonstrating the safety of these nutraceutical ingredients and excipients.

Conclusions: CollabZenTM, with its known antioxidant and collagen-boosting properties and current findings can be considered a valuable nutraceutical product for the anti-ageing sector of the cosmetic industry.


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Original Research Articles