Anti-ageing effects of CollabZen™ in healthy human volunteers: a randomized, double blind, placebo-controlled study

Mihir C. Gadani; Sneha Badak; Ratna Upadhyay

doi:10.18203/2349-3259.ijct20240303

Authors

Mihir C. Gadani Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India
Sneha Badak Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India
Ratna Upadhyay Department of Phytochemistry, Zenherbs Lab Pvt Ltd, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3259.ijct20240303

Keywords:

CollabZenTM, Nutraceuticals, Skin ageing, Nutrition, Phytocompound

Abstract

Background: There are several concerns related to combating signs of ageing. Considering the long-term safety concerns of cosmetic formulations, a safe and effective approach using nutritional supplements and naturals should be of great help. CollabZen^TM is one such a blend of three plant materials known as Phyllanthus emblica, Camellia sinensis, and Coffea arabica, earlier tested for collagen building in human cells in-vitro. The current study aims to explore its potential as a nutraceutical product for skin ageing.

Methods: The study enrolled 64 volunteers both genders (mean age=45.75) with crow's feet wrinkles. One group (n=32) received a placebo capsule (Product A) and other group received CollabZen^TM capsules (Product B). Dermatological parameters were assessed at 0^th day, 4^th and 8^th week, and self-assessment questionnaires for efficacy and tolerance were collected on 4^th and 8^th week. The trial is registered at https://ctri.nic.in/, CTRI/2022/10/046168.

Results: The results showed that product B (CollabZen^TM) was significantly effective than the placebo in improving deep skin hydration on the face (p=0.009), increasing facial skin elasticity (p=0.001), and enhancing firmness (p=0.001) after 8 weeks. Participants in Group B reported higher levels of satisfaction regarding their perceived skin health compared to group A based on self-assessment at the 8^th weeks (p<0.01). Moreover, only one volunteer in each group experienced mild intolerance at the end of 8th week, demonstrating the safety of these nutraceutical ingredients and excipients.

Conclusions: CollabZen^TM, with its known antioxidant and collagen-boosting properties and current findings can be considered a valuable nutraceutical product for the anti-ageing sector of the cosmetic industry.

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