The efficacy of ranolazine in improving glycemic parameters in patients with type 2 diabetes mellitus: a meta-analysis


  • Oliver Allan C. Dampil Department of Medicine, St. Lukes Medical Center Quezon City, Philippines
  • Sybil Claudine R. Luy Department of Medicine, St. Lukes Medical Center Quezon City, Philippines
  • Bayocot Jayson De Lara Department of Medicine, St. Lukes Medical Center Quezon City, Philippines
  • Rojo Rialyn Department of Medicine, St. Lukes Medical Center Quezon City, Philippines
  • Tingchuy Avilyn Raquel Department of Medicine, St. Lukes Medical Center Quezon City, Philippines



Ranolazine, Type 2 diabetes mellitus, Glycemic parameters, Meta-analysis, Diabetes treatment


Ranolazine is an anti-anginal drug that mediates its effects by inhibition of cardiac late sodium current. Although it is not indicated for the treatment of type 2 diabetes mellitus (T2DM), several clinical trials have shown that ranolazine was associated with a reduction in HbA1c. The objective of this meta-analysis is to determine the efficacy and safety of ranolazine in improving glycemic control in patients with T2DM. A total of five randomized controlled trials involving 2,680 patients were included in the analysis. The pooled analysis showed that ranolazine may improve glycemic control with a modest decrease in HbA1c and FBS. The difference in HbA1c was -0.38% (95% CI -0.59 to -0.17), favoring ranolazine. Sensitivity analysis showed a difference of HbA1c of -0.49% (CI -0.67, -0.31), still favoring the ranolazine group. There was also a statistically significant difference in fasting glucagon, favoring the ranolazine group (-2.70 pg/ml: 95% CI -5.24 to -0.16). The risk of hypoglycemia with ranolazine was comparable with placebo (RR 1.27 95% CI 0.84 to 1.91). Overall, ranolazine appears to be a safe and effective option for improving glycemic control in patients with T2DM, with a modest decrease in HbA1c and FBS, and a lower risk of hypoglycemia compared to placebo. However, further studies are needed to confirm these findings and to investigate the long-term safety and efficacy of ranolazine in this patient population.


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