The value of clinical trial medication and yearly medicine cost avoidance from clinical trials conducted by the pharmaceutical industry in Finland
Keywords:Cost avoidance, Medication cost avoidance, MCA, Industry-sponsored clinical trials, Pharmaceutical industry, Finland
Background: Clinical trials have been reported to cause medication cost avoidance (MCA) for hospitals and societies, but there are no studies documenting MCA from the Nordic countries or from the pharmaceutical industry perspective.
Methods: Three different methods were tested for determining the yearly MCA in clinical trials conducted by the pharmaceutical industry in Finland. MCA was evaluated with questionnaires to pharmaceutical companies operating in Finland in 2001, 2009 and 2013.
Results: In method 1 (year 2001), the MCA in Finland was 70.3 million euros in wholesale price and 50.9 million euros when excluding patients receiving placebo treatment. In method 2 (2009), the MCA was 52.0 million euros in wholesale price and 71.0 million euros in out-sale price i.e. including pharmacy fee and tax. The MCA in method 3 (2013) was 47.2 million euros in wholesale price. The collection of data and the MCA calculation was simple in method 1 (response rate 100%). The methods 2 and 3 were more precise but more time-consuming for the respondents, somewhat affecting the response rate (response rates 90% and 72%, respectively).
Conclusions: All three methods covered the majority of industry-sponsored clinical medicine trials (64-100%) representing 59-63 % of all clinical trials conducted in Finland in those years. Regardless of the methods, the study medications provided by the pharmaceutical industry promoted significant cost saving for the society. We recommend method 1 for a general and less time consuming MCA calculation and method 3 for a more precise calculation, to be conducted in survey format and interview.
Clinical trial statistics 2018. Available at: www.fimea.fi. Accessed on 20 February 2023.
Applied Clinical Trials; Scorr Marketing. Available at: https://www.appliedclinicaltrialsonline.com/ view/global-trends-survey-report-august-2017. Accessed on 20 February 2023.
LaFleur J, Tyler LS, Sharma RR. Economic benefits of investigational drug services at an academic institution. Am J Heal Pharm. 2004;61(1):27-32.
Bredin C, Eliasziw M, Syme R. Drug cost avoidance resulting from cancer clinical trials. Contemp Clin Trials. 2010;31(6):524-9.
Shen LJ, Chou H, Huang CF, Chou GM, Chan WK, Wu FL. Economic benefits of sponsored clinical trials on pharmaceutical expenditures at a medical center in Taiwan. Contemp Clin Trials. 2011;32(4):485-91.
Liniker E, Harrison M, Weaver JM, Agrawal N, Chhabra A, Kingshott V, et al. Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009-2010). Br J Cancer. 2013;109(8):2051-7.
Tang PA, Hay AE, O'Callaghan CJ, Mittmann N, Chambers CR, Pater JL, et al. Estimation of drug cost avoidance and pathology cost avoidance through participation in NCIC Clinical Trials Group phase III clinical trials in Canada. Curr Oncol. 2016;23(1):S7-S13.
Mañes-Sevilla M, Romero-Jiménez R, Herranz-Alonso A, Sánchez-Fresneda M, Gonzalez-Haba E, Collado-Borrel R, et al. Drug cost avoidance in clinical trials of breast cancer. J Oncol Pharm Pract. 2019; 25(5):1099-1104.
Truong K, Kwan YL, Nigro L, Huseincehajic A, Trotman J. Retrospective pharmaceutical financial benefits and cost avoidance analysis of clinical trial participation in the Australian haematology setting. Intern Med J. 2019;49(9):1092-8.
Lamas MC, Álvarez MTR, García FB, Herranz I. Drug cost avoidance in rheumatology clinical trials. Eur J Clin Pharm. 2014;16(4):266-72.
Kaló Z, Antal J, Pénzes M, Pozsgay C, Szepezdi Z, Nagyjánosi L. Contribution of clinical trials to gross domestic product in Hungary. Croat Med J. 2014; 55(5):446-51.
Structure and principles. Available at: https://www. whocc.no/atc/structure_and_principles/. Accessed on 20 February 2023.
Pharmaintelligence Informa. Pharma R&D Annual Review 2019. Available at: https://pharmaintelligence.informa.com/~/media/ informa-shop-window/pharma/2019/files/white papers/pharma-rd-review-2019-whitepaper.pdf. Accessed on 20 February 2023.
Heistaro S, Halila H, Myllymäki K. Tutkimusrahoitus on saatava nousu-uralle. Available at: https://www. laakarilehti.fi/ajassa/paakirjoitukset/ tutkimusrahoitus-on-saatava-nousu-uralle/?public= 64ad137293 be321c62b3d3805d75f15e. Accessed on 20 February 2023.