A systemic review of clinical trials of COVID-19, registered in WHO-ICTRP
Keywords:COVID-19, Registered clinical trial, ICTRP, Interventional trial, Observational trial
In September 2004, International Commission of Medical Journal Editors implemented a dramatic and important policy for the condition of publication of clinical trials. The condition was that clinical trials must be registered in a public trial registry. World Health Organization-International Clinical Trials Registry Platform (WHO-ICTRP) is the globally centralised network composed of primary registries and partner registries along with data providers. COVID-19 is a pandemic and a significant social and economical health burden. In this event numbers of trials have been undertaken by the medical professionals and research workers in every part of the world. Here we have analysed registered clinical trials for the detection, treatment and prevention of COVID-19 to provide a summary of global response w.s.r.to WHO-ITCRP. The objective of this study was to collect the data of registered clinical trials for the therapeutic and preventive measures for COVID-19 which are registered in WHO-ICTRP and analyse global response of COVID-19. WHO-ITCRP database has 20 fields of mapping. Out of these, we have analysed 6 fields of this registry, for this study purpose: public title, scientific title, study type, countries, intervention and primary outcome. Clinical trials are focused on chloroquine, hydroxychloroquine, lopinavir ritonavir combination, Remdesivir, Favipiravir, Tocilizumab and Interferon. Also, it is seen that convalescent plasma therapy is a promising intervention. Observational trials are directed mainly on the clinical features and distinguish COVID-19 from other influenza like illnesses.
ICMJE.org. Available at: http://icmje.org/news-and-editorials/clin_trial_sep2004.pdf. Accessed on 19 April 2020.
ICMJE.org. Available at: http://icmje.org/about-icmje/faqs/clinical-trials-registration/. Accessed on 19 April 2020.
De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med. 2004;141:477-8.
CTRI. Available at: http://ctri.nic.in/Clinicaltrials/ login.php. Accessed on 17 April 2020.
WHO. Available at: https://www.who.int/ictrp/en/. Accessed on 21 April 2020.
Prathap Tharyan. The WHO International Clinical Trials Registry Platform: Relevance to the Indian register of clinical trials The National Med J India 2006;19(3):161.
Glanville JM, Duffy S, McCool R, Varley D. Searching ClinicalTrials.gov and the International Clinical Trials Registry Platform to inform systematic reviews: what are the optimal search approaches? J Med Lib Assoc. 2014;102(3):177-83.
CEBM. Available at: https://www.cebm.net/ COVID-19/registered-trials-and-analysis/ Accessed on 20 April 2020.
Cochrane Library. Available at: https://www. cochranelibrary.com/central/central-creation. Accessed on 19 April 2020.
Aronson JK, Ferner RE, DeVito N, Heneghan C. COVID-19 Registered Trials – and analysis March 17, 2020. Available at: https://www.cebm.net/ COVID-19/registered-trials-and-analysis/. Accessed on 20 April 2020.
Zhu R, Gao R, Robert S, Gao J, Yang S, Zhu C. Systematic Review of the Registered Clinical Trials of (Covid19). J Transl Med. 2020;18:274.
Available at: https://www.ema.europa.eu/en/human-regulatory/overview/advanced-therapy-medicinal- products-overview. Accessed on 20 April 2020.
Global coalition to accelerate COVID-19clinical research in resource-limited settings April 2, 2020 Available at: https://www.thelancet.com/journals/ lancet/article/PIIS0140-6736(20)30798-4/fulltext# seccestitle10pdf. Accessed on 24 April 2020.
Lythgoe MP, Middleton P. Ongoing Clinical Trials for the Management of the COVID-19 Pandemic. Trends Pharmacol Sci. 2020;41(6):363-82.
Available at: https://www.medrxiv.org/content/10. 1101/2020.03.01.20029611v2. Accessed on 20 April 2020.
Available at: https://www.who.int/news-room/ commentaries/ detail/advice-on-the-use-of-point-of-care-immunodiagnostic-tests-for-COVID-19. Accessed on 20 April 2020.
Available at: https://www.fda.gov/news-events/ public-health-focus/expanded-access. Accessed on 22 April 2020.
Available at: https://www.wepclinical.com/ expanded-access-programs/. Accessed on 22 April 2020.
Available at: https://www.who.int/emergencies/ diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-COVID-19-treatments. Accessed on 21 April 2020.
Hannah Balfour European Pharmaceutical Review COVID-19 update: running clinical trials during the corona virus pandemic 7 April 2020. Available at: https://www.europeanpharmaceuticalreview.com/article/116456/COVID-19-update-running-clinical-trials-during-the-coronavirus-pandemic/. Accessed on 24 April 2020.
Wilkinson M, Dumontier M, Aalbersberg I, et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data. 2016;3:160018.