Investigation on nutrition status and clinical outcome of patients with common cancers in Chinese patients: a multicenter prospective study protocol


  • Hongxia Xu Department of Clinical Nutrition, Daping Hospital, Army Medical University, Chongqing, China
  • Chunhua Song Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China
  • Chang Wang Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China
  • Zhenming Fu Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
  • Zengqing Guo Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China
  • Yuan Lin Department of Gastrointestinal Surgery, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China
  • Yingying Shi Department of Surgery, The First Affiliated Hospital of SunYat-sen University, Guangzhou, Guangdong, China
  • Wen Hu Department of Clinical Nutrition, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • Yi Ba Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
  • Suyi Li Department of Nutrition and Metabolism of Oncology, Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui, China
  • Zengning Li Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
  • Kunhua Wang Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
  • Jing Wu Department of Clinical Nutrition, The First People's Hospital of Kashi, Xinjiang, China
  • Ying He Department of Clinical Nutrition, Chongqing General Hospital, Chongqing, China
  • Jiajun Yang Department of Colorectal and Anal Surgery, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
  • Conghua Xie Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
  • Fuxiang Zhou Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
  • Xinxia Song Department of Oncology, Xingtai People’s Hospital, Hebei Medical University, Xingtai, Hebei, China
  • Gongyan Chen Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China
  • Wenjun Ma Department of Nutrition, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
  • Suxia Luo Department of Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China
  • Zihua Chen Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
  • Minghua Cong Comprehensive Oncology Department, National Cancer Center or Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Hu Ma Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Chunling Zhou The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China
  • Wei Wang Cancer center, The First People's Hospital of Foshan, Foshan, Guangdong, China,
  • Qi Luo Department of Gastrointestinal Tumor Surgery, The First Affiliated Hospital, Xiamen University, Xiamen, Fujian, China
  • Yongmei Shi Department of Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • Yumei Qi Department of Nutrition, Tianjin Third Central Hospital, Tianjin, China
  • Haiping Jiang Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China
  • Wenxian Guan Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China
  • Junqiang Chen Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
  • Jiaxin Chen Department of Radiation and Medical Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
  • Yu Fang Department of Clinical Nutrition, Peking University Cancer Hospital and Institute, Beijing, China
  • Lan Zhou Department of Nutrition, Third Affiliated Hospital of Kunming Medical College, Tumor Hospital of Yunnan Province, Kunming, Yunnan, China
  • Yongdong Feng Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • Rongshao Tan Department of Nutrition, Guangzhou Red Cross Hospital, Guangzhou, Guangdong, China
  • Tao Li Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu, Sichuan, China
  • Junwen Ou Department of Clinical Nutrition, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
  • Qingchuan Zhao Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi, China
  • Jianxiong Wu Department of Hepatobiliary Surgery, National Cancer Center or Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Min Weng Department of Clinical Nutrition, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
  • Qinghua Yao Department of Integrated Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital and Key Laboratory of Traditional Chinese Medicine Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
  • Wei Li Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China
  • Hanping Shi Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Beijing, China, Department of Oncology, Capital Medical University or Ninth Clinical Medical College, Peking University, Beijing, China



Nutritional status, Nutritional assessment, Malnutrition, Patient-generated subjective global assessment, Bodyweight loss, Karnofsky performance status score, Quality of life


Background: Malnutrition is common in patients with cancer, which adversely affects the survival and quality of life of cancer patients. However, there is no national data on the prevalence of malnutrition in Chinese cancer patients. This study aims to evaluate the prevalence of malnutrition and quality of life (QOL) of Chinese patients with local regional, recurrent or metastatic cancer, to address the prognostic value of nutritional status and QOL on the survival of cancer patients in China and to validate the patient-generated subjective global assessment (PG-SGA) questionnaire in Chinese cancer patients.

Methods: This is an observational, multi-centered, and hospital-based prospective cohort study. We aimed to recruit 50,000 cancer patients (age 18 and above) over an 8-year period. Data collection will occur within 48 hr after patients are admitted to hospital, 30-days after hospital admission, and the follow-up will be conducted 1-8 years after enrolment. The primary outcome is overall survival, and secondary outcomes are length of hospital stay and hospital costs. Factors measured are demographic characteristics, tumor characteristics, anthropometry measurements, hematological measurement, body composition, PG-SGA scores, Karnofsky performance status scores, and QLQ C30 scores. This protocol was approved by local ethical committees of all the participant hospitals.

Conclusions: This multi-centered, large-scale, long-time follow-up prospective study will help diagnose malnutrition in cancer patients in China, and identify the related risk factors associated with the negative outcomes. The anticipated results will highlight the need for a truly scientific appraisal of nutrition therapy, and help to improve outcomes among cancer patients in China.

Trial Registration: The trial has been registered with the Chinese Clinical Trial Registry, ChiCTR1800020329. Registered on 19 December 2018.

Author Biography

Hongxia Xu, Department of Clinical Nutrition, Daping Hospital, Army Medical University, Chongqing, China

Department of Clinical Nutrition


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