Platelet transfusion in a dengue epidemic as per recent WHO classification

Authors

  • Smita Mahapatra Department of Transfusion Medicine, S.C.B. Medical College, Cuttack, Odisha, India
  • Ansuman Sahu
  • Dibyajyoti Sahoo
  • Satyabrata Patjoshi
  • Pankaj Parida

DOI:

https://doi.org/10.5455/2349-3259.ijct20140507

Keywords:

Dengue, Platelet, Thrombocytopenia

Abstract

Background: The objective was to study the role of platelet transfusion in a dengue epidemic as management to the reduced platelet count and associated hemorrhagic manifestations.

Methods:The study was conducted for a period of four months over 3115 cases of clinically and serologically positive cases of dengue for non-structural protein antigen (NS 1).

Results:The patients diagnosed as dengue fever without warning signs constituted the maximum number of cases 2418 (77.6%) followed by dengue fever with warning signs 667 (21.4%), severe dengue 30 (1.0%). In serologically confirmed cases, only 154 patients had platelet count <10000/cumm. The prevalence of bleeding was reported in 667 cases and platelet was transfused in only 724 cases constituting 508 cases of dengue with warning signs and 30 cases of severe dengue.

Conclusion:Prophylactic platelet transfusion can be done in thrombocytopenic patients with platelet count less than 10000/cumm and associated hemorrhagic manifestations with count more the above label.

References

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World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. In: WHO, eds. WHO Guidelines. Geneva, Switzerland: WHO; 2009: 3-147.

Directorate of NVBDCP, Govt. of India. Guidelines for clinical management of dengue fever, dengue haemorrhagic fever and dengue shock syndrome. In: NVBDCP, eds. NVBDCP Guideline. Delhi: Directorate of NVBDCP; 2008: 1-33.

Kumar ND, Tomar V, Singh B, Kela K. Platelet transfusion practice during dengue fever epidemic. Indian J Pathol Microbiol. 2000;43:55-60.

Directorate General of Health Services. Guidelines for clinical management of dengue fever, dengue haemorrhagic fever/dengue shock syndrome. In: DGHS, eds. DGHS Guideline. Delhi: Directorate General of Health Services; 2008: 29.

The Ministry of Health, Singapore. Management of guidelines for dengue patients at Tan Tock Seng hospital and communicable diseases center, Singapore: platelet transfusion. Epidemiologic News Bull. 2005;31(3):49.

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Published

2014-05-01

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Section

Original Research Articles