Evaluation of neo adjuvant chemotherapy response in patients with locally advanced breast cancer


  • Nallamothu Murali Krishna Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh
  • C. Mandava Radha Mani Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh
  • Veera Abhinav Chinta Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh
  • T. Jaya Chandra Central Research Laboratory, GSL Medical College, Rajahmundry, Andhra Pradesh




Breast, Cancer, Chemotherapy


Background: Carcinoma of the breast from the very beginning has been a feared disease. Advanced disease is treated by neoadjuvant chemotherapy (NACT). With this, a study was conducted to evaluate the pathologic response to NACT in locally advanced breast cancer.

Methods: Study was conducted in GSL Medical College, approved by institutional ethics committee, females aged >18 years with locally advanced breast cancer were included in the study. Female <18 years and breast cancer male were not considered. The dimensions are marked and size of the lump compared before and after NACT. Chi-square test was used to find out the significance of study parameters; p<0.05 was considered statistically significant.

Results: Total 110 patients were included in the study, mean age was 50.63±10.76 years and 53% were in pre menopausal women. When pathological response was considered, 12.7% had complete response, 66.4% had partial response and 20.9% had no response to NACT; statistically there was significant difference between pre and post treatment tumor sizes (p<0.05).

Conclusions: Most of the individuals belonged to premenopausal group. Tumour size showed significant decrease after NACT. The overall response rate (complete and partial) after NACT was significant in our study group.


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