DOI: http://dx.doi.org/10.18203/2349-3259.ijct20170310

Clinical appraisal of Lodhradi Kashaya on type 2 diabetes mellitus patients

Varun K. Singh, K. R. C. Reddy

Abstract


Background: Lodhradi Kashaya (LKSD) is basically ayurvedic kwath dosage form, described as Madhumehajeet (winner of diabetes mellitus) in ayurvedic classics Basavarajeeyam and the same formulation in Vaidya Chintamani and Charaka Samhita too. The aim of this study was to assess prospectively the drug’s ability in management of type 2 diabetes.

Methods: Total 31 patients were taken following the guideline mention in CCRAS protocol for diabetes mellitus research. They are divided into two groups, group A and B, given LKSD 4 g & 2 g TDS respectively for three-month follow up. They are investigated against their blood glucose, HbA1C and liver profile tests. Patients were also investigated for subjective parameters viz polyurea, polyphagia, exhaustion and constipation and their response has also been noted regarding palatability acceptance and ease of administration.

Results: Patients has responded positively for formulation. Decrease in FBS and PPBS were found highly significant (P ˂ 0.001) in both groups but more in higher dose (group A). Decrease in HbA1C is also found highly significant in both groups. In LFT, SGOT level were also decreased more in group B in comparison to group A, and it is significant (P = 0.017 and 0.002). SGPT level were also decreased more in group B in comparison to group A, and it is significant in group B (P= 0.085 and 0.002).  

Conclusions: LKSD is having astringent taste due to tannins and phenols in it. It was found significant not only in controlling blood sugar but also in management of other factors related to diabetes mellitus.


Keywords


Ayurveda, Lodhradi Kashaya, Diabetes mellitus, Clinical study

Full Text:

PDF

References


Murthy ARV, Singh RH. Concept of Prameha/Madhumeha (Contradictions and Compromises). Ancient Sci Life. 1989;9:71-9.

Anonymous. Guidelines for the Management of Type 2 Diabetes, 1st edition. New Delhi: Indian Council of Medical Research; 2005: 1.

10 Fact about Diabetes. Available at http://www.who.int/features/factfiles/diabetes/facts/en/index9.html. Accessed 10 November 2015.

Shane-Mc Whorter L. American Diabetes Associations Guide to Herbs and Nutritional Supplements. New York: Mcgraw-Hill; 2009: 328-339.

Neelkanth B, Lavekar GS. Basavarajiyam. New Delhi: Central Council for Research in Ayurvedic Sciences; 2007: 329.

Vallabhacharya. Vaidya Chintamani. Reddy KRC, editors. Varanasi: Chaukhambha Orientalia Publication; 2013: 779-780.

Lavekar GS. Clinical Research protocol for Traditional Health Sciences. New Delhi: CCRAS; 2009: 459-477.

Singh VK, Reddy KRC. Pharmaceutical processing and standardization of modified dosage form of Lodhradi Kashaya as spray dried powder. Int J Green Pharm. 2015;9:252-6.

Das B, Mitra A, Hazra J. Management of Madhumeha (Diabetes mellitus) with evidence and intervention with Ayurvedic Rasaushadhies. Indian J Tradit Knowle. 2011;10:624-8.

Mehra R, Makhija R, Vyas N. Role of Terminalia chebula on Gastrointestinal Mucosa. Research J Pharma Technol. 2012;5:1183-6.

Tripathi VN, Tewari SK, Gupta JP, Chaturvedi GN. Clinical trial of haritaki (Terminalia chebula) in treatment of simple constipation. Sachitra Ayurved. 1983;35:733-40.

The International Expert Committee. International Expert committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327–34.

Satyavani K, Aravindalochanan V, Rajan R, Viswanathan V, Kapur A. Evaluation of performance of A1c and FPG tests for screening newly diagnosed diabetes defined by an OGTT among tuberculosis patients - A study from India. Diabetes Res Clin Practice. 2013;102;60-4.

Ali L, Azad Khan AK, Mamun MIR, Mosihuzzaman M, Nahar N, Alan MNE, et al. Studies on the hypoglycemic effects of fruits pulp, seed and whole plant of Momordica charantia on normaland diabetic model rats. Planta Med. 1993;59:408-12.

Gray AM, Abdel-Wahab YHA, Flatt PR. The traditional plant treatment, Sabucus nigra (Elder), exhibits insulin-like and insulin releasing actions in vitro. J Nutrition. 2000;130:15–20.

Kamanyi A, Dajmen D, Nkeh B. Hypoglycemic properties of the aqueous root extract of Morinda lucida (Rubiacea) study in the mouse. Phytother Research. 1994;8:369–71.

Rokeya B, Nahar N, Ali L, Hassan Z, Alam MNE, Choudhury SN, et al. Effects of five medicinal plants on blood glucose levels in non-diabetic and diabetic model rats. Diabetes Res. 1999;34:219-28.

Shanmugasundaram ERB, Gopinath KL, Shanmugasundaram KR, Rajendran VM. Possible regeneration of the islets of Langerhans in streptozotocindiabetes rats given Gymnema sylvetre leaf extracts. J Ethnopharmacol. 1990;30:265-79.

Raut N. Antidiabetic Potential of Fractions of Hydro-Ethanol Extract of Cyperus rotundus L. (Cyperaceae). Res J Pharm Biol Chem Sci. 2012;3:1014.

Krisanapun C, Wongkrajang Y, Temsiririrkkul R, Kongsaktrakoon B, Peungvicha P. Anti-diabetic effect and acute toxicity of the water extract of Cyperus rotundus L. in rats. FASEB J. 2012;26:686-8.

Panthari P. Evaluate the antidiabetic activity of Myrica esculenta leaves in streptozotocin induced diabetes in rat. In J Univ Pharm Bio Sci. 2013;2:510-25.

Khare CP. Indian Medicinal Plants An Illustrated Dictionary. New York: Springer Science+BusinessMedia; 2007: 428-429.

SenthilKumar GP, Arulselvan P, Kumar DS, Subramanian SP. Antidiabetic activity of fruits of Terminalia chebula on Streptozotocin induced Diabetic rats. J of Health Sci. 2006;52:283-91.

SenthilKumar GP, Arulselvan P, Subramanian SP. Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J Appl Biomed. 2008;6:105–15.

Wakchaure D, Jain D, Singhai AK, Somani R. Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats. J Ayurveda Integr Med. 2011;2:137-43.

Singh VK, Reddy KRC. Management of diabetes mellitus and its complications by Lodhra: A review. Int J Ayurvedic Med. 2015;6:305-9.

Choi M, Kim HG, Han JM, Lee JS, Lee JS. Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice. J Evid Based Complementary Altern Med. 2015:Article ID 517350.

Suresh Kumar SV, Mishra SH. Hepatoprotective activity of rhizomes of Cyperus rotundus Linn against carbon tetrachloride-induced hepatotoxicity. Indian J Pharm Sci. 2005;67:84-8.